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Sibutramine (usually in thе form of thе hydrochloride monohydratе salt) is an oral anorеxiant. Until rеcеntly it was markеtеd and prеscribеd as an adjunct in thе trеatmеnt of еxogеnous obеsity along with diеt and еxеrcisе. Sibutraminе is a cеntrally-acting sеrotonin-norеpinеphrinе rеuptakе inhibitor structurally rеlatеd to amphеtaminеs, although its mеchanism of action is distinct.
USAGE OF SIBUTRAMINE
Take exactly as prescribed by your medical practioner. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Sibutramine is usually taken once daily. Follow your medical practioner's instructions. Your medical practioner may occasionally change your dose of Sibutramine to make sure you get the best results. Sibutramine can be taken with or without food. You should lose at least 4 pounds during the first 4 weeks of taking Sibutramine and eating a low calorie diet. Discuss with a pharmacist if you do not lose at least 4 pounds after taking the medication for 4 weeks. Your blood pressure and pulse will need to be checked often. Visit your medical practioner regularly. Sibutramine should not be taken for longer than 2 years.
Store at room temperature away from moisture, heat, and light. Do not share Sibutramine with another person. Keep the medication in a place where others cannot get to it.
SIDE EFFECTS OF SIBUTRAMINE
Major side effects:
- fast, pounding, or uneven heartbeats;
- new or worsening shortness of breath;
- agitation, hallucinations, fever, tremor, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, dilated pupils;
- very stiff (rigid) muscles, high fever, sweating, confusion, feeling like you might pass out;
- easy bruising or bleeding (nosebleeds, bleeding gums, or any bleeding that will not stop);
- dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, seizure);
- chest pain or heavy feeling, pain spreading to the arm or shoulder, general ill feeling; or
- Sudden numbness or weakness (especially on one side of the body), problems with vision, speech, or balance.
Minor side effects:
- dry mouth, upset stomach;
- changes in appetite;
- constipation, stomach pain;
- headache, back pain, joint pain;
- feeling nervous, dizzy, or depressed;
- flu symptoms, runny or stuffy nose, sore throat, cough;
- warmth, redness, or tingly feeling under your skin;
- trouble sleeping (insomnia); or
- Mild skin rash.
DOSAGE OF SIBUTRAMINE
Usual Adult Dose for Obesity:
Sibutramine was voluntarily withdrawn from the US market by the manufacturer in October, 2010 due to clinical trial data indicating an increased risk of heart attack and stroke. The following dosage information applies to when the drug was available in the US.
Initial Dose: 10 mg orally once a day.
Usual Geriatric Dose for Obesity:
Clinical studies of Sibutramine did not include sufficient numbers of patients over 65 years of age. Sibutramine is contraindicated in this group of patients.
Usual Pediatric Dose for Obesity:
The following Sibutramine dosage information applies to when the drug was available in the US.
Based on one study (n=60)
14 to 17 years:
Initial Dose: 10 mg orally once a day.
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