Lorazepam is used for treating anxiety. It is considered that excessive activity of nerves in the brain might root anxiety and other psychological disorders. Gamma-aminobutyric acid (GABA) is a neurotransmitter, a chemical that nerves in the brain use to send messages to one another. GABA reduces the activity of nerves in the brain. Lorazepam  and other benzodiazepines may act by enhancing the effects of GABA in the brain. Because Lorazepam  is removed from the blood more rapidly than many other benzodiazepines, there is less chance that Lorazepam  concentrations in blood will reach high levels and become toxic. Lorazepam  also has fewer interactions with other medications than most of the other benzodiazepines.

Zolpidem is a sedative, also called a hypnotic. It affects chemicals in your brain that may become unbalanced and cause sleep problems (insomnia). Zolpidem is employed to treat insomnia. The immediate-release form of Zolpidem is Ambien, which is employed to help you fall asleep. The extended-release form of Zolpidem is Ambien CR, which has a first layer that dissolves quickly to help you fall asleep, and a second layer that dissolves slowly to help you stay asleep.